Kombiglyze XR⁚ An In-Depth Look
**Kombiglyze XR** is a prescription medication used to treat **type 2 diabetes** in adults. It is not suitable for individuals with type 1 diabetes or diabetic ketoacidosis. This article will delve into the details of Kombiglyze XR, including its uses, dosage, side effects, and important warnings.
What is Kombiglyze XR?
Kombiglyze XR is a single tablet that combines two medications⁚
- **Saxagliptin**⁚ This belongs to a class of drugs called **dipeptidyl peptidase-4 (DPP-4) inhibitors**, which help lower blood sugar levels by increasing the amount of insulin released by the body and decreasing the amount of sugar produced by the liver.
- **Metformin**⁚ This belongs to a class of drugs called **biguanides**, which lower blood sugar levels by decreasing the amount of sugar produced by the liver and improving the body’s response to insulin.
How is Kombiglyze XR Used?
Kombiglyze XR is prescribed alongside diet and exercise to manage blood sugar levels in individuals with type 2 diabetes. The dosage is individualized based on the patient’s current regimen, effectiveness, and tolerability.
* **Dosage⁚** Kombiglyze XR is typically taken **once daily with the evening meal**. The dosage is gradually increased to minimize gastrointestinal side effects associated with metformin.
* Available forms⁚ Kombiglyze XR comes in two strengths⁚ 5 mg saxagliptin / 500 mg metformin and 5 mg saxagliptin / 1000 mg metformin.
What are the Side Effects of Kombiglyze XR?
Like any medication, Kombiglyze XR can cause side effects. Some common side effects include⁚
* Headache
* Nausea
* Diarrhea
* Upper respiratory tract infection
* Urinary tract infection
Serious side effects can also occur, though less frequently. These include⁚
* Lactic acidosis⁚ This is a rare but potentially life-threatening condition caused by a buildup of lactic acid in the blood. Symptoms may include muscle pain, weakness, unusual sleepiness, trouble breathing, stomach pain, nausea/vomiting, dizziness, lightheadedness, or slow/irregular heartbeat. If you experience any of these symptoms, seek immediate medical attention.
* Pancreatitis⁚ Inflammation of the pancreas.
* Severe joint pain⁚ This can be debilitating and may require stopping the medication.
Important Warnings
* Lactic acidosis⁚ Individuals with kidney problems, liver problems, or congestive heart failure are at a higher risk of developing lactic acidosis. It’s crucial to discuss your medical history with your doctor before starting Kombiglyze XR.
* Vitamin B12 deficiency⁚ Metformin can interfere with vitamin B12 absorption. Your doctor may monitor your vitamin B12 levels and recommend supplementation if necessary.
* Hypoglycemia⁚ Low blood sugar can occur, especially when used with other medications for diabetes. Be aware of the symptoms of hypoglycemia, such as sweating, shakiness, dizziness, hunger, and confusion.
* Surgery or medical procedures⁚ Inform your doctor if you are scheduled for surgery or any medical procedures, as you may need to temporarily stop taking Kombiglyze XR.
Additional Information
* Pregnancy and breastfeeding⁚ It’s important to discuss the risks and benefits of Kombiglyze XR with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
* Drug interactions⁚ Certain medications can interact with Kombiglyze XR. Inform your doctor about all medications and supplements you are taking.
Disclaimer⁚ This information is not a substitute for professional medical advice. Always consult with your doctor or pharmacist for personalized guidance regarding your medication.